A Promising Link Between BLIS K12™ And Autoimmune Modulation

Published August 13, 2025

Autoimmune diseases affect millions, causing chronic inflammation, pain, and tissue damage. Most current treatments only manage symptoms, not root causes. BLIS K12™ (Streptococcus salivarius) emerges as a potential breakthrough by targeting the oral microbiome—a key factor in immune regulation. Imbalances in the oral microbiome can increase inflammation and disrupt immune function. By restoring this balance, BLIS K12™ may actively regulate immunity and reduce symptoms in autoimmune conditions like rheumatoid arthritis (RA) and psoriasis. Discover the BLIS K12 health benefits for autoimmune system support and take a step closer to a healthier, more balanced life.

In this article, we’ll examine the science behind BLIS K12™, its mechanisms of action, and the latest research exploring its potential in autoimmune modulation.

Autoimmune Diseases And The Need For New Approaches

Autoimmune diseases develop when the immune system inaccurately assaults the body’s healthy tissues, treating them as threats. This response can damage joints, skin, organs, or other systems, resulting in chronic inflammation and ongoing harm. Examples include rheumatoid arthritis, psoriasis, lupus, and multiple sclerosis.

Autoimmune diseases have become a growing health concern worldwide, affecting an estimated 5–10% of the population. Notably, many of these conditions are more commonly found in women.

Challenges And Side Effects Of Current Treatments

Medications like corticosteroids, biologics, and disease-modifying antirheumatic drugs (DMARDs) have improved symptom management. However, they have notable drawbacks. These include a higher risk of infections, potential liver toxicity, and sometimes a shorter lifespan. Many of these treatments also focus on symptoms rather than the root of the condition.

The Rising Interest In Probiotic-Based Therapies

Researchers are increasingly focusing on the oral microbiome—a community of microorganisms in the mouth—as it may influence autoimmune conditions. Dysbiosis, or an imbalance in this microbial community, can disrupt immune signals and trigger inflammation. Targeted probiotics like BLIS K12™ may help restore oral microbial balance, providing a natural alternative to drugs without unwanted side effects.

What Is BLIS K12™ And How Does It Work?

BLIS K12™ is a patented strain of Streptococcus salivarius. This beneficial bacterium is naturally found in the mouths of healthy individuals. It was first isolated from the saliva of a New Zealand child with excellent throat health. BLIS K12™ produces lantibiotics, which are antimicrobial peptides like Salivaricin A and Salivaricin B.

These lantibiotics play a crucial role in suppressing harmful oral pathogens, including:

• Porphyromonas gingivalis (linked to gum disease and systemic inflammation)
• Fusobacterium nucleatum (associated with inflammatory conditions)
• Streptococcus pyogenes (responsible for strep throat and certain autoimmune complications)

Role In Immune Modulation

Emerging research highlights BLIS K12™’s potential to modulate immune responses. It may interact with IL-6 and IL-21 receptors, key regulators of inflammation and immune cell activity. By reducing bacteria that trigger pro-inflammatory cytokines like IL-17, BLIS K12™ promotes immune balance and lowers inflammation.

Applications For Health

BLIS K12™ is a core ingredient in advanced formulations like BioNaze, which pairs it with Bifidobacterium lactis BL-04. These probiotics support oral, sinus, and respiratory health, providing a powerful boost to overall well-being.