The Science Behind BL-04
One of the active ingredients in Bionaze™
What Is BL-04™?
Bifidobacterium lactis for Immunity, Hay Fever and Allergies
Growing evidence shows that our bodies resident microbiome interacts with our immune system and may even influence immune responses; and Bifidobacteria strains, specifically BL-04™ appear to be one of the best probiotics for this purpose.
Summaries From Recent Studies Done On Bl-04
In a randomised, double blind, placebo-controlled study, 115 participants were administered with ‘rhinovirus’ i.e. given the cold virus. The group was also given the strain Bifidobacterium lactis BL-04 28 days before and during the rhinovirus challenge. Results showed a reduced incidence of respiratory tract infection as well as ‘viral shedding’, i.e. the replication / spread of the virus, in the probiotic group compared to placebo.
A human study evaluated the ability of B. lactis BL-04 to encourage a healthy immune reaction in response to a vaccination. Human volunteers were orally vaccinated against cholera, and then given either a placebo or one of seven different probiotic strains including B. lactis BL-04 for a period of 21 days. Via blood serum and saliva testing, significant changes in immunoglobulin serum concentrations were found in 6 out of the 7 probiotic supplementation groups, whereas no changes were observed in the control group. Those in the BL-04 group showed increased IgG in an early response to the vaccine (Paineau et al. 2008).
In another randomised trial, 47 children with hay fever triggered by birch tree pollen were given a probiotic containing a combination of Lactobacillus acidophilusNCFM® and Bifidobacterium lactis BL-04 or placebo. Those taking the two strain combination were found to have a significantly reduced presence of eosinophils (a type of white blood cell which is involved in controlling allergies) in the nose area, compared to the placebo group. Additionally, the participants reported that those on the two-strain probiotic had reduced symptoms of nasal congestion and discharge, compared to those in the placebo group (Ouewhand AC et al, 2009).
Read The Scientific Studies Read Studies Done On The BL-04 Probiotic Strain
In a recent double-blind, randomised, placebo-controlled study in Australia, 465 healthy participants who exercised regularly were selected. The aim of the study was to determine whether probiotics would help to support immune function in these subjects, as significant exercise can put a strain on the immune system causing an increased risk of colds and respiratory infections. The subjects were divided into three groups: Group 1 were given the probiotic strain B. lactis BL-04 alone; Group 2 were given a combination of L. acidophilus NCFM® & B. lactis BL-07, and Group 3 were given a placebo. Over the 5 months of the trial, it was found that Group 1 displayed a 27% lower incidence of upper respiratory infections. Those in Group 2 also showed a decreased incidence of infection, though results were not as strong as in group 1; however, both groups displayed improved immunity compared to the placebo group which had no impact on infection risk reduction (West NP et al, 2014).
BL-04 is mostly found in the large intestines of mammals including humans. Experts are generally interested in its potential for improving gastrointestinal function, immunity and enhancing the side effects of antibiotics.
A recent study has proven its effect on people who are infected with the “rhinovirus” more commonly known as the cold virus. These people were given the BL-04 probiotic strain for about two months. They exhibited reduced respiratory tract infection and the spreading of virus was effectively contained.
A clinical trial also revealed that BL-04 can be used to treat nasal allergies. Children with hay fever caused by a birch tree pollen were administered with a dose of BL-04 and Lactobacillus Acidophilus. Results indicated that their eosinophils in the nose area are reduced. Eosinophils are white blood cells that control allergies. They have also shown lesser incidence of nasal congestion and discharge.
Doubts as to whether its safe for human consumption have already been addressed by several previous studies. It’s even present in several types of foods we consume daily. The European Food Safety Authority even added it to the Qualified Presumption of Safety list. The EU also hasn’t detected any acquired antibiotic resistance from consuming this probiotic strain.