The Science Behind Bifidobacterium Lactis BL-04
One of the active ingredients in Bionaze™
Your Guide To Bifidobacterium Lactis BL-04
The immune system shields the body from diseases and infections by responding to harmful microorganisms. However, many may not realize that the gut bacterial population is key to supporting proper immune system function.
Recent research shows the microbiome plays a key role in immune health. This ecosystem of microbes lives within our bodies. An imbalance in this delicate system can create a cascade of reactions that weaken immunity. Studies highlight the importance of probiotics like Bifidobacterium lactis BL 04 strain. These can help promote and maintain a healthy immune system.
Researchers have focused on probiotics, often called “good bacteria,” to solve this issue. These microorganisms help restore balance in the microbiome and boost immune health.
Among the many probiotic strains, one stands out: Bifidobacterium lactis BL-04. It has been extensively studied. It shows promising benefits for immune function and digestive health. It may also help reduce the risk of respiratory infections. Learn more about the top scientifically backed probiotics here.

Read The Scientific Studies Read Studies Done On The BL-04 Probiotic Strain
What Is Bifidobacterium Lactis BL-04?
Bifidobacterium lactis BL-04 is a probiotic found in healthy intestines. It’s an anaerobic, rod-shaped microorganism. Studies show it may offer several health benefits, including:
- Enhancing immune function
- Supporting healthy digestion
- Mitigating the side effects of antibiotics
This strain naturally exists in the human body and some foods. It’s considered safe to consume, and no adverse effects are known.
Health Benefits Of Bifidobacterium Lactis BL-04
Similar to other probiotic strains, Bifidobacterium lactis BL-04 offers targeted health benefits. Its central role is to support and regulate the immune system, so adding probiotics with this strain may provide several health advantages.
Resistance To Stomach Acid
One of the most impressive features of Bifidobacterium lactis BL-04 is its resistance to stomach acid. Many probiotics are destroyed by stomach acid before they reach the gut—but not BL-04. Its resilience helps more viable bacteria reach your intestines. There, they defend against harmful microbes and support gut health.
Interaction With The Intestinal Tract
Research indicates that Bifidobacterium lactis BL-04 can adhere firmly to the intestinal lining, allowing it to remain in the gut for an extended period. This proximity to intestinal immune cells enables it to modulate immune responses and sustain gut health more effectively.
Boosts Antiviral Defenses
A 2024 study examined the effects of Bifidobacterium lactis BL-04 on human immune cells. Researchers found that this probiotic boosts cytokine production. It also enhances the response of macrophages and dendritic cells during viral challenges, highlighting its potential to strengthen antiviral immune responses. The study found that Bifidobacterium lactis BL 04 strain had no significant impact on rhinovirus replication and did not affect cytokine production in fibroblasts. This suggests its benefits may be specific to certain immune cell types.
A 2023 study scrutinized the impact of Bifidobacterium animalis subsp. lactis BL-04 on influenza A virus infection among mice. Researchers found that administering the strain before and after infection changed the gut microbiota and boosted innate immune responses. This led to a reduced viral load and milder infection symptoms. The findings suggest that the strain holds promise as a potential therapeutic agent for combating influenza infections.
Alleviates Seasonal Allergies
Research suggests that probiotics may help reduce seasonal allergy symptoms. A 2009 study tested children with birch pollen allergies. They were given a mix of Lactobacillus acidophilus and Bifidobacterium lactis BL-04. The treatment lasted four months before pollen season.
The results were promising. Participants had fewer symptoms, such as nasal congestion, runny noses, and watery eyes. There was also a clear drop in eosinophil cells, a marker of allergic inflammation.
Recent studies explore the strain’s impact on hay fever. They highlight its potential to promote immune tolerance. The research also shows promise in reducing allergic reactions.
Enhances Immune Response To Vaccines
A study with 83 participants looked at probiotics and vaccine efficacy. It included the Bifidobacterium lactis BL 04 strain. Participants were vaccinated against cholera and took probiotics for 21 days.
Results showed a remarkable increase in IgG antibodies in those who received the probiotic strain. The findings suggest it may boost the body’s immune response to vaccines.
Reduces Risk Of The Common Cold
A randomized, placebo-controlled trial explored the effectiveness of Bifidobacterium animalis subsp. Lactis BL-04 prevents colds caused by rhinovirus. Healthy participants took the probiotic daily for 28 days before rhinovirus exposure. They showed fewer cold symptoms compared to the placebo group. The study also found positive effects on the gut microbiome and immune responses. This highlights its potential to help fight viral infections.
Bifidobacterium lactis for Immunity, Hay Fever and Allergies
Growing evidence shows that our bodies resident microbiome interacts with our immune system and may even influence immune responses; and Bifidobacteria strains, specifically BL-04™ appear to be one of the best probiotics for this purpose.

Summaries From Recent Studies Done On Bifidobacterium Lactis BL-04
In a randomized, double-blind, placebo-controlled study, 115 participants were deliberately exposed to the cold virus (rhinovirus). Before and during this challenge, one group received the probiotic strain Bifidobacterium lactis BL-04 for 28 days. The findings showed that the probiotic group had fewer respiratory tract infections and reduced viral shedding. This means less virus replication and spread compared to the placebo group.
A human study explored the effects of Bifidobacterium lactis BL-04 on immune response after vaccination. Volunteers received an oral cholera vaccine. They were then assigned to take a placebo or one of seven probiotic strains, including Bifidobacterium lactis BL-04, for 21 days. Blood serum and saliva tests showed increased immunoglobulin levels in six probiotic groups. No changes were seen in the control group. The Bifidobacterium lactis BL-04 group showed an early rise in IgG levels. This suggests a strong immune response to the vaccine (Paineau et al., 2008).
A randomized trial studied the effects of a probiotic on 47 children with hay fever caused by birch tree pollen. Participants received either a probiotic blend or a placebo. The probiotic included Lactobacillus acidophilus NCFM® and Bifidobacterium lactis BL-04. Children in the probiotic group had fewer eosinophils. These white blood cells are linked to allergies. The reduction was seen in their nasal passages. They also reported improvements in symptoms like nasal congestion and discharge. These results suggest this two-strain probiotic may help reduce allergy symptoms (Ouwehand AC et al., 2009).
Bifidobacterium lactis BL-04 is found in the large intestines of mammals, including humans. It may support gastrointestinal health and strengthen the immune system. Researchers are also studying its potential to reduce antibiotic side effects.
A recent study shows that Bifidobacterium lactis BL-04 is effective against the common cold caused by the rhinovirus. Participants took the probiotic for two months. They had fewer respiratory tract infections, and the spread of the virus was also greatly reduced.
A clinical trial found that Bifidobacterium lactis BL-04 can help treat nasal allergies. The study focused on children with hay fever caused by birch tree pollen. They were given the Bifidobacterium lactis BL 04 strain and Lactobacillus Acidophilus. Results showed a significant drop in eosinophils, the white blood cells that trigger allergic reactions in the nose. Additionally, the children experienced fewer symptoms, including nasal congestion and discharge.
Many studies have established its safety for human consumption. It’s already present in many foods we eat daily. The European Food Safety Authority lists it on its Qualified Presumption of Safety list. The EU has also found no evidence of antibiotic resistance from consuming this probiotic strain.
A recent study in Australia examined the effects of probiotics on immune health. It was double-blind, randomized, and placebo-controlled. The study included 465 healthy participants who exercised regularly. Rigorous physical activity can weaken the immune system, making people more prone to colds and respiratory infections. Participants were split into three groups. Group 1 received Bifidobacterium lactis BL-04, Group 2 received L. acidophilus NCFM® combined with B. lactis BL-07, and Group 3 received a placebo. The trial lasted five months. Group 1 saw a 27% reduction in upper respiratory infections. Group 2 also had fewer infections, though the effect was smaller than Group 1. Both probiotic groups showed better immunity than the placebo group. The placebo group had no significant reduction in infection risk. This study shows that probiotics can support immune function. This is especially true for persons with active lifestyles that strain their immune systems (West NP et al., 2014).
Reduces Antibiotic Side Effects
Antibiotics are essential for killing harmful bacteria. However, they can disrupt your gut microbiome. They often eliminate beneficial microbes, too. This imbalance may cause digestive issues. In a randomized trial, participants under antibiotics took a multi-strain probiotic with Bifidobacterium lactis BL-04. The results were precise. The probiotic group had less microbiome disruption. They also maintained higher levels of beneficial bifidobacteria. These benefits lasted two weeks after finishing antibiotics.
Safe And Readily Accessible
Bifidobacterium lactis BL-04 has been part of the human diet for generations. It’s commonly present in fermented dairy products like yogurt and cheese. This strain is also a key ingredient in many probiotic supplements. It’s often paired with other beneficial strains to boost effectiveness.
One notable supplement featuring Bifidobacterium lactis BL-04 is Bionaze, specially designed to support the health of the nose, ears, throat, and mouth. This oral probiotic comes in a convenient lozenge form, ensuring targeted delivery where needed most.
How Often Should You Take BL-04 Probiotics?
Consistency is key to fully benefiting from Bifidobacterium lactis BL-04 probiotics. Think of your gut microbiome as a garden. Without care, harmful bacteria can take over, weakening beneficial bacteria, harming your immune system, and making you more prone to illness.
Probiotics help restore balance to your gut and support overall health and resilience. A stronger immune system starts with a healthy gut. Add the Bifidobacterium lactis BL 04 strain to your daily routine for long-term wellness.
BL-04 Side Effects
The European Food Safety Authority (EFSA) has confirmed the safety of Bifidobacterium lactis BL-04. There is no evidence of harmful side effects. This strain has also been added to the Qualified Presumption of Safety (QPS) list, affirming its safety when consumed as directed. Furthermore, no signs of acquired antibiotic resistance have been identified in BL-04.
Before starting a new probiotic, consult your healthcare provider. This is especially important if you have health concerns or take other medications.

About The Author
Hi, I’m Corinne Grace, a proud nursing graduate from Riverside College with a flair for writing. I specialize in health and wellness topics, using my educational background to weave informative and attention-grabbing articles that appeal to a wide variety of readers. Committed to excellence in writing, I’m always refining my skills to stay in sync with the fast-evolving world of digital media. Whether you’re seeking to understand complex health concepts or looking for relatable advice, I’m here to deliver content that’s accurate and enjoyable to read.